Manifestation of pathognomonic signs in modeling diabetes mellitus with streptozotocin in BALB/c mice

Relevance. Diabetes mellitus is a widespread, socially significant disease. In this regard, it important to obtain an experimental model that precedes subsequent experiments on pharmacological screening and/or study of the mechanism action antidiabetic agents. The aim work was comparative assessment manifestation hyperglycemia, DNA damage, and morphology internal organs in BALB/c mice modeling diabetes by single administration streptozotocin at dose 200 mg/kg its fractional, five-day rate 40 per day. Methods. Streptozotocin used as inducer diabetes. drug administered once or 5 times daily mg/kg. We monitored damage cells brain, liver, kidneys, pancreas testes, also assessed microscopic picture individual organs, including pancreas. Results. both variants experiment, reproduction pathognomonic signs traced. They are somewhat more clearly seen variant experiment with doses